The next generation of RNA vaccines: self-amplifying RNA

The global COVID-19 pandemic has brought tremendous momentum to the field of messenger RNA (mRNA) vaccines. advantages this vaccine platform, such as rapid development and high efficacy, resulted in mRNA vaccines being first approved against COVID-19. Looking forward future vaccines, how can we make even better? While improvements stability formulation cost are inevitable, one main challenges is lowering dose order avoid side effects associated with doses RNA. One way do by using self-amplifying (saRNA), a type that encodes replicase copies original strand once it’s cell. Here, discuss origins saRNA, it works comparison mRNA, current saRNA